Epidermal growth factor receptor - Wikipedia, the free encyclopedia
cell-surface receptor for members of the epidermal growth factor family
(EGF-family) of extracellular protein ligands.[2]
The epidermal growth factor receptor is a member of the ErbB family of
receptors, a subfamily of four closely related receptor tyrosine
kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4
(ErbB-4). Mutations affecting EGFR expression or activity could result
in cancer.[3]
Epidermal growth factor and its receptor was discovered
by Stanley Cohen of Vanderbilt University. Cohen shared
the 1986 Nobel Prize in Medicine with Rita Levi-Montalcini for their
discovery of growth factors.
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the"Inflammatory disease - Aberrant EGFR signaling has been implicated in psoriasis, eczema and atherosclerosis.[10][11] However, its exact roles in these conditions are ill-defined."
cell-surface receptor for members of the epidermal growth factor family
(EGF-family) of extracellular protein ligands.[2]
The epidermal growth factor receptor is a member of the ErbB family of
receptors, a subfamily of four closely related receptor tyrosine
kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4
(ErbB-4). Mutations affecting EGFR expression or activity could result
in cancer.[3]
Epidermal growth factor and its receptor was discovered
by Stanley Cohen of Vanderbilt University. Cohen shared
the 1986 Nobel Prize in Medicine with Rita Levi-Montalcini for their
discovery of growth factors.
