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Sunday, 20 July 2014

Treat Psoriasis by Modifying Paleo » The Paleo Mom

Modifying Paleo to Treat Psoriasis » The Paleo Mom

April 19, 2012by
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In the paleo community, we are accustomed to assuming that a standard paleo diet will cure (or at least significantly improve) virtually every health problem.  But, if you have psoriasis (or dermatitis or eczema), be prepared:  paleo not only may fail to resolve these skin conditions, it might even make it worse.  Now, don’t go running for the hills.  The principles behind the paleo diet are still sound.  It is still the best way to eat for your long-term health.  And there are certainly some people who find complete resolution of their psoriasis symptoms with the switch to a paleo diet (for those people, the root cause of the psoriasis is typically a gluten sensitivity).  For me (and for many others), switching to paleo made my psoriasis worse.  This isn’t because paleo has us on the wrong track; it’s simply because out-of-the-box paleo is not actually enough.

I am a long term sufferer of lichen planus, a form of psoriasis where the inflammation occurs in the mucosal layer of the skin (and very unnerving, you can actually get lesions in the gut mucosa as well!).  In fact, it was my search for a cause (and hopefully cure) for this condition that brought me to paleo in the first place!  All my other health issues either completely resolved or improved substantially within weeks of switching to a paleo diet, but my lichen planus did not improve.  If anything, it got worse.  But since paleo was working so well for me in every other respect, my search for a solution stayed within a paleo framework.

What you might not know (and certainly I didn’t) was that psoriasis (and dermatitis and eczema) is an autoimmune disease.  It’s not always listed in those lists of autoimmune diseases that can be put into full remission by a paleo diet (it is listed in The Paleo Answer, but not The Paleo Diet nor The Paleo Solution).  Why is it so often left out?  I guess it’s because when compared to Lupus, Multiple Sclerosis or Non-Hodgkin’s lymphoma, psoriasis is small potatoes.  And let’s just take a moment to appreciate how lucky we are that, when our bodies formed antibodies against our own cells, we only ended up with psoriasis!

Psoriasis is also an indicator of a severely leaky gut (that’s how we develop the autoimmunity in the first place), with a very high likelihood of Small Intestinal Bacterial Overgrowth.  It is also very commonly linked to a gut-brain connection problem with inflammation and autoimmunity targeting skin cells.  I went into some details about the gut-brain connection in this post, but I also recommend listening to the explanation of the gut-brain-skin axis that Chris Kresser gives in his Revolution Health Radio podcast episode titled “Naturally Get Rid Of Acne By Fixing Your Gut”.  There is a complex interplay between a leaky gut, a stressed body, loss of insulin and leptin sensitivity, mood issues, food sensitivities, and the inflammation that manifests as psoriasis.  Basically, if you suffer psoriasis, chances are your gut, your immune system and your hormones are all really messed up.

So, what do you do about psoriasis?  The first and most important step is to follow the paleo diet “autoimmunity protocol”.  This means that in addition to all of the foods we already avoid while eating paleo, we must also avoid:

    Eggs (especially the whites)
    Nuts and Seeds (or at least severely restrict quantities)
    Nightshades (tomatoes, eggplant, peppers of all kinds)

We are also people who Can Not Cheat.  Ever.  We can not tolerate any dairy, not even grass-fed butter or ghee.  Food quality becomes extremely important, so the more we can eat grass-fed meat, wild-caught fish, pastured eggs and chicken, and organic vegetables, the better (I know it’s expensive and I certainly can’t afford this 100%, but I just do the best I can).  And we are people who can’t tolerate very much sugar (even the sugars in fruits) or starches (even from superfoods like sweet potatoes) as they tend to feed the organisms in Small Intestinal Bacterial Overgrowth.  It would be worthwhile to have a look at the GAPS diet food list as an indicator of which fruits and vegetables should be avoided (although I wouldn’t suggest starting with the GAPS diet protocol unless you really have tried everything else).  And that’s not all.  Because stress hormones can play a key role in the perpetuation of psoriasis, it is especially important for us to get lots and lots of high quality sleep, avoid excessive caffeine intake (or cut it out completely), severely limit alcohol consumption (or avoid it completely), get lots of low-strain exercise, manage the stress in our lives, get sun exposure and take a Vitamin D3 supplement (on the higher dose side; I take 12,000IU per day in addition to trying to get outside every day).  I also suggest reading my recommendations on Repairing The Gut.  In particular, I suggest incorporating organ meat into your diet at least twice per week, consuming bone broth or other collagen-rich foods (like gelatin, stew hens and heart meat) at least twice per week (every day would be even better), consuming fermented foods (like raw Sauerkraut or coconut milk kefir) every day, and consuming coconut oil every day (I like it in my coffee).

So how long until you see some results?  You should start to see improvement very quickly, within a couple of days for some people up to 3-4 weeks for others.  If you do not see improvement within a month, you may also have developed additional food sensitivities (your gut is leaky, after all).  If doing all of the above still isn’t enough to see improvement in your symptoms, it would be worth finding a physician, naturopathic doctor, or chiropractor who will order an IgG and IgA food sensitivity blood test (you might also investigate Small Intestinal Bacterial Overgrowth, internal yeast infections and parasite infections as possible confounding factors as well).  These food sensitivities are transient and once your gut has healed (and at least 6 months have passed without exposure), you should be able to reintroduce the foods.  Actually, you should be able to reintroduce eggs, nuts and seeds, higher sugar fruits and vegetables and maybe even nightshades at some point in the future as well.  Are you wondering how long this is going to take?  I’m afraid the answer is anywhere between 2 months and 2 years, depending on exactly what the root causes are for you.  But, if you could see how much my lichen planus has improved in 3½ months, you would be amazed.  I know that the extra dietary restrictions are tough, but it is worth it to be able to cure such an aggravating condition without the use of steroids.  And the thing to keep in mind is that once the psoriasis is gone, out-of-the-box paleo really will be enough for us.

Monday, 14 July 2014

Lipid peroxidation and tissue damage. [In Vivo. 1999 May-Jun] - PubMed - NCBI

Lipid peroxidation and tissue damage. [In Vivo. 1999 May-Jun] - PubMed - NCBI


Mylonas C1, Kouretas D.

Abstract

In recent years it has become apparent that the oxidation of lipids, or lipid peroxidation, is a crucial step in the pathogenesis of several disease states in adult and infant patients. Lipid peroxidation is a process generated naturally in small amounts in the body, mainly by the effect of several reactive oxygen species (hydroxyl radical, hydrogen peroxide etc.). It can also be generated by the action of several phagocytes.

These reactive oxygen species readily attack the polyunsaturated fatty acids of the fatty acid membrane, initiating a self-propagating chain reaction. The destruction of membrane lipids and the end-products of such lipid peroxidation reactions are especially dangerous for the viability of cells, even tissues. Enzymatic (catalase, superoxide dismutasse) and nonenzymatic (vitamins A and E) natural antioxidant defence mechanisms exist; however, these mechanisms may be overcome, causing lipid peroxidation to take place.

Since lipid peroxidation is a self-propagating chain-reaction, the initial oxidation of only a few lipid molecules can result in significant tissue damage. Despite extensive research in the field of lipid peroxidation it has not yet been precisely determined if it is the cause or an effect of several pathological conditions. Lipid peroxidation has been implicated in disease states such as atherosclerosis, IBD, ROP, BPD, asthma, Parkinson's disease, kidney damage, preeclampsia and others.

PMID:
    10459507
    [PubMed - indexed for MEDLINE]




Lipid peroxidation - Wikipedia, the free encyclopedia

Lipid peroxidation - Wikipedia, the free encyclopedia


Lipid peroxidation refers to the oxidative degradation of lipids. It is the process in which free radicals "steal" electrons from the lipids in cell membranes, resulting in cell damage. This process proceeds by a free radical chain reaction mechanism. It most often affects polyunsaturated fatty acids, because they contain multiple double bonds in between which lie methylene bridges (-CH2-) that possess especially reactive hydrogens. As with any radical reaction, the reaction consists of three major steps: initiation, propagation, and termination. 

Epidermal growth factor receptor - Wikipedia, the free encyclopedia

Epidermal growth factor receptor - Wikipedia, the free encyclopedia

"Inflammatory disease - Aberrant EGFR signaling has been implicated in psoriasis, eczema and atherosclerosis.[10][11] However, its exact roles in these conditions are ill-defined."

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the
cell-surface receptor for members of the epidermal growth factor family
(EGF-family) of extracellular protein ligands.[2]

The epidermal growth factor receptor is a member of the ErbB family of
receptors, a subfamily of four closely related receptor tyrosine
kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4
(ErbB-4). Mutations affecting EGFR expression or activity could result
in cancer.[3]

Epidermal growth factor and its receptor was discovered
by Stanley Cohen of Vanderbilt University. Cohen shared
the 1986 Nobel Prize in Medicine with Rita Levi-Montalcini for their
discovery of growth factors.